Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 20 Reviews
8.2
Supplement Facts
Serving Size: 3/4 Level Teaspoon (approx. 3 g)
Amount Per Serving
%DV
Glycine (Free-Form)
3 g (3,000 mg)
**
Top Medical Research Studies
8
Autologous stem cell transplant shows promise
We examined a remarkable instance of a patient with glycine receptor antibody-positive stiff person syndrome (SPS) treated with autologous hematopoietic stem cell transplant (aHSCT) as part of a clinical trial. Over an 18-month period, the patient showed significant improvement in various clinical metrics, such as mobility and stiffness.
This highlights the potential of aHSCT as a beneficial treatment option for those with SPS, emphasizing the need for consistent outcome measures in future studies. However, it's important to note that this study, being observational with no control group, calls for further research to validate these findings.
This highlights the potential of aHSCT as a beneficial treatment option for those with SPS, emphasizing the need for consistent outcome measures in future studies. However, it's important to note that this study, being observational with no control group, calls for further research to validate these findings.
7
We conducted a review of medical records and serum evaluations at the Mayo Clinic to explore childhood-onset stiff-man syndrome (SMS), a rarely reported condition. Over 29 years, we identified eight young patients with symptoms starting before age 18, revealing various phenotypes, including classic SMS and a severe variant.
Treatment yielded benefits, with many patients responding well to symptomatic therapies and immunotherapy. However, about half still experienced moderate to severe symptoms, indicating that while treatable, the management of SMS requires ongoing attention.
Treatment yielded benefits, with many patients responding well to symptomatic therapies and immunotherapy. However, about half still experienced moderate to severe symptoms, indicating that while treatable, the management of SMS requires ongoing attention.
Most Useful Reviews
9
Restful sleep achieved
15 people found this helpful
My doctor advised that my child take glycine, but domestic versions were ineffective. After reading positive reviews, I tried iHerb’s glycine. Remarkably, within three days of use, my child slept soundly through the night and woke restored. We have settled on 1/3 teaspoon twice daily. I was sceptical at first but am now convinced of its efficacy and have reordered.
9
Enhanced concentration observed
9 people found this helpful
I ordered glycine for both myself and my mother, and we both noticed significant improvements compared to Russian products. I felt much more focused, as if I were meditatively prepared to work. My mother reported greatly improved sleep quality, feeling energetic and well-rested upon waking. This product is truly impressive!
9
Enhances sleep quality
3 people found this helpful
I was advised by my naturopath to use glycine both to lower my estrogen levels due to endometriosis and to combat inflammation, particularly to achieve deep, restorative sleep. I now take 10 grams at night, and in under 20 minutes, I drift off! Initially, I struggled with sleepless nights, but this product has changed that. I'm discovering more dreams and waking up refreshed, which is remarkable. Glycine has become a staple in my nighttime routine.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Autologous stem cell transplant shows promise
We examined a remarkable instance of a patient with glycine receptor antibody-positive stiff person syndrome (SPS) treated with autologous hematopoietic stem cell transplant (aHSCT) as part of a clinical trial. Over an 18-month period, the patient showed significant improvement in various clinical metrics, such as mobility and stiffness.
This highlights the potential of aHSCT as a beneficial treatment option for those with SPS, emphasizing the need for consistent outcome measures in future studies. However, it's important to note that this study, being observational with no control group, calls for further research to validate these findings.
This highlights the potential of aHSCT as a beneficial treatment option for those with SPS, emphasizing the need for consistent outcome measures in future studies. However, it's important to note that this study, being observational with no control group, calls for further research to validate these findings.
7
We conducted a review of medical records and serum evaluations at the Mayo Clinic to explore childhood-onset stiff-man syndrome (SMS), a rarely reported condition. Over 29 years, we identified eight young patients with symptoms starting before age 18, revealing various phenotypes, including classic SMS and a severe variant.
Treatment yielded benefits, with many patients responding well to symptomatic therapies and immunotherapy. However, about half still experienced moderate to severe symptoms, indicating that while treatable, the management of SMS requires ongoing attention.
Treatment yielded benefits, with many patients responding well to symptomatic therapies and immunotherapy. However, about half still experienced moderate to severe symptoms, indicating that while treatable, the management of SMS requires ongoing attention.
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restful sleep achieved
15 people found this helpful
My doctor advised that my child take glycine, but domestic versions were ineffective. After reading positive reviews, I tried iHerb’s glycine. Remarkably, within three days of use, my child slept soundly through the night and woke restored. We have settled on 1/3 teaspoon twice daily. I was sceptical at first but am now convinced of its efficacy and have reordered.
9
Enhanced concentration observed
9 people found this helpful
I ordered glycine for both myself and my mother, and we both noticed significant improvements compared to Russian products. I felt much more focused, as if I were meditatively prepared to work. My mother reported greatly improved sleep quality, feeling energetic and well-rested upon waking. This product is truly impressive!
9
Enhances sleep quality
3 people found this helpful
I was advised by my naturopath to use glycine both to lower my estrogen levels due to endometriosis and to combat inflammation, particularly to achieve deep, restorative sleep. I now take 10 grams at night, and in under 20 minutes, I drift off! Initially, I struggled with sleepless nights, but this product has changed that. I'm discovering more dreams and waking up refreshed, which is remarkable. Glycine has become a staple in my nighttime routine.
9
Effective for elderly
1 people found this helpful
I bought glycine for my mother to help her sleep better as age had made it difficult for her to do so. The impact has been substantial; it’s far more effective than the glycine we previously purchased from the pharmacy. She sleeps much better now, which has improved her overall wellbeing.
7.5
Gut healing effects
1 people found this helpful
I began using glycine to help heal my gut from glyphosate damage, a chemical in pesticides that can lead to leaky gut syndrome. Since I started taking it, I drink it daily mixed with food or drink—it's easily dissolvable, and I've noticed fewer gut issues over time. I believe this has contributed to my overall wellbeing, including addressing some effects of autoimmune disorder.
Frequently Asked Questions
9
Restful sleep achieved
15 people found this helpful
My doctor advised that my child take glycine, but domestic versions were ineffective. After reading positive reviews, I tried iHerb’s glycine. Remarkably, within three days of use, my child slept soundly through the night and woke restored. We have settled on 1/3 teaspoon twice daily. I was sceptical at first but am now convinced of its efficacy and have reordered.
9
Sound sleep regained
4 people found this helpful
I have suffered from sleep disorders for three years, but after taking this glycine, I have finally achieved sound sleep! I take 3 grams before bed, alongside one tablet of GABA. It has a slightly rough texture, akin to granulated sugar, yet it works wonderfully for me, and I plan to continue this regimen indefinitely.
7.5
Gut healing effects
1 people found this helpful
I began using glycine to help heal my gut from glyphosate damage, a chemical in pesticides that can lead to leaky gut syndrome. Since I started taking it, I drink it daily mixed with food or drink—it's easily dissolvable, and I've noticed fewer gut issues over time. I believe this has contributed to my overall wellbeing, including addressing some effects of autoimmune disorder.
7.5
Deeper sleep experienced
3 people found this helpful
After years of disrupted sleep, I found that this glycine deepened my rest significantly. I melted a teaspoon in hot water each night before bed; the results were profound, leading to inability to rise the next morning due to deep sleep. Being powder, it allows for precise adjustments according to one's condition, making it an effective solution.
9
Enhanced concentration observed
9 people found this helpful
I ordered glycine for both myself and my mother, and we both noticed significant improvements compared to Russian products. I felt much more focused, as if I were meditatively prepared to work. My mother reported greatly improved sleep quality, feeling energetic and well-rested upon waking. This product is truly impressive!
7.5
Mood enhancement
I have a family member with a severe mood disorder. He discovered that combining glycine with L-glutamine and L-threonine significantly boosts his mood.
7.5
Balances sleep patterns
4 people found this helpful
Glycine is notable for lowering cortisol and adrenaline, facilitating better sleep recovery. It's most effective taken on an empty stomach before bed. Its dosage ranges from 2 to 4 grams. I genuinely find that it helps balance my sleep patterns, which have been disrupted due to stress. Although there are some contraindications, I've found that when coupled with magnesium, it works wonders for my sleep quality.
8
Autologous stem cell transplant shows promise
We examined a remarkable instance of a patient with glycine receptor antibody-positive stiff person syndrome (SPS) treated with autologous hematopoietic stem cell transplant (aHSCT) as part of a clinical trial. Over an 18-month period, the patient showed significant improvement in various clinical metrics, such as mobility and stiffness.
This highlights the potential of aHSCT as a beneficial treatment option for those with SPS, emphasizing the need for consistent outcome measures in future studies. However, it's important to note that this study, being observational with no control group, calls for further research to validate these findings.
This highlights the potential of aHSCT as a beneficial treatment option for those with SPS, emphasizing the need for consistent outcome measures in future studies. However, it's important to note that this study, being observational with no control group, calls for further research to validate these findings.
7
We conducted a review of medical records and serum evaluations at the Mayo Clinic to explore childhood-onset stiff-man syndrome (SMS), a rarely reported condition. Over 29 years, we identified eight young patients with symptoms starting before age 18, revealing various phenotypes, including classic SMS and a severe variant.
Treatment yielded benefits, with many patients responding well to symptomatic therapies and immunotherapy. However, about half still experienced moderate to severe symptoms, indicating that while treatable, the management of SMS requires ongoing attention.
Treatment yielded benefits, with many patients responding well to symptomatic therapies and immunotherapy. However, about half still experienced moderate to severe symptoms, indicating that while treatable, the management of SMS requires ongoing attention.
References
- Celli SI, Nash R, Money KM, Garza M, Borko TL, et al. Successful Autologous Hematopoietic Stem Cell Transplant in Glycine Receptor Antibody-Positive Stiff Person Syndrome: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2024;11:e200197. doi:10.1212/NXI.0000000000200197
- Clardy SL, Lennon VA, Dalmau J, Pittock SJ, Jones HR, et al. Childhood onset of stiff-man syndrome. JAMA Neurol. 2013;70:1531. doi:10.1001/jamaneurol.2013.4442
